Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

Groß, Steffen; Knebel, Axel; Tenev, Tencho; Neininger, Armin; Gaestel, Matthias; Herrlich, Peter; D. Böhmer, Frank

doi:10.1074/jbc.274.37.26378

Public

Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

Published in Journal of Biological Chemistry • Sep 1, 1999

Authors:

Steffen Groß

Axel Knebel

Tencho Tenev

Abstract

UV irradiation of cells causes ligand-independent activation of receptor tyrosine kinases. On the basis of dephosphorylation kinetics, UV-induced inactivation of receptor-directed tyrosine phosphatases (PTP) has been proposed as the mechanism of receptor activation (Knebel, A., Rahmsdorf, H. J., Ull...

Subject

Dephosphorylation

Protein tyrosine phosphatase

Receptor tyrosine kinase

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!