H <sub>2</sub> S Signals Through Protein S-Sulfhydration

K. Mustafa, Asif; M. Gadalla, Moataz; Sen, Nilkantha; Kim, Seyun; Mu, Weitong; K. Gazi, Sadia; K. Barrow, Roxanne; Yang, Guangdong; Wang, Rui; H. Snyder, Solomon

doi:10.1126/scisignal.2000464

Public

H 2 S Signals Through Protein S-Sulfhydration

Published in Science Signaling • Nov 10, 2009

Authors:

Asif K. Mustafa

Moataz M. Gadalla

Nilkantha Sen

Abstract

Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. We now show that H2S physiologically modifies cysteines in a large number of proteins by S-sulfhydration. About 10 to 25% of many...

Subject

Hydrogen sulfide

Cysteine

Chemistry

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