Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Angulo, Ivan; Vadas, Oscar; Garçon, Fabien; Banham-Hall, Edward; Plagnol, Vincent; R. Leahy, Timothy; Baxendale, Helen; Coulter, Tanya; Curtis, James; Wu, Changxin; Blake-Palmer, Katherine; Perisic, Olga; Smyth, Deborah; Maes, Mailis; Fiddler, Christine; Juss, Jatinder; Cilliers, Deirdre; Markelj, Gašper; Chandra, Anita; Farmer, George; Kielkowska, Anna; Clark, Jonathan; Kracker, Sven; Debré, Marianne; Picard, Capucine; Pellier, Isabelle; Jabado, Nada; A. Morris, James; Barcenas-Morales, Gabriela; Fischer, Alain; Stephens, Len; Hawkins, Phillip; C. Barrett, Jeffrey; Abinun, Mario; Clatworthy, Menna; Durandy, Anne; Doffinger, Rainer; R. Chilvers, Edwin; J. Cant, Andrew; Kumararatne, Dinakantha; Okkenhaug, Klaus; L. Williams, Roger; Condliffe, Alison; Nejentsev, Sergey

doi:10.1126/science.1243292

Public

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Shared by NobleBlocks on Nov 15, 2013 • 12:00 AM UTC

Authors:

Ivan Angulo

Oscar Vadas

Fabien Garçon

Abstract

Answers from Exomes Exome sequencing, which targets only the protein-coding regions of the genome, has the potential to identify the underlying genetic causes of rare inherited diseases. Angulo et al. (p. 866 , published online 17 October; see Perspective by Conley and Fruman ) performed exome seque...

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