Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

Kato, Shigeaki; Endoh, Hideki; Masuhiro, Yoshikazu; Kitamoto, Takuya; Uchiyama, Shimami; Sasaki, Haruna; Masushige, Shoichi; Gotoh, Yukiko; Nishida, Eisuke; Kawashima, Hiroyuki; METZGER, Daniel; Chambon, Pierre

doi:10.1126/science.270.5241.1491

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Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

Published in Science • Dec 1, 1995

Authors:

Shigeaki Kato

Hideki Endoh

Yoshikazu Masuhiro

Abstract

The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1). This Ser118 is phosphorylated by mitogen-activated protein kinase (MAPK) in vitro and in cells treated with epidermal growth factor (EGF) and i...

Subject

MAPK/ERK pathway

Protein kinase A

Phosphorylation

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