T25: A Simplified Carcinogenic Potency Index: Description of the System and Study of Correlations between Carcinogenic Potency and Species/Site Specificity and Mutagenicity

Dybing, Erik; Sanner, Tore; Roelfzema, H.; Kroese, Dinant; W. Tennant, Raymond

doi:10.1111/j.1600-0773.1997.tb01973.x

Public

T25: A Simplified Carcinogenic Potency Index: Description of the System and Study of Correlations between Carcinogenic Potency and Species/Site Specificity and Mutagenicity

Published in Pharmacology & Toxicology • Jun 1, 1997

Authors:

Erik Dybing

Tore Sanner

H. Roelfzema

Abstract

A simplified carcinogenic potency index, the T25, is proposed as a practical method for the inclusion of potency considerations in carcinogen classification systems. The T25 is the chronic daily dose in mg per kg bodyweight which will give 25% of the animals tumours at a specific tissue site, after ...

Subject

Carcinogen

Potency

Toxicology

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