Docetaxel‐induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model

Roglio, Ilaria; Bianchi, Roberto; Camozzi, Francesca; Carozzi, Valentina; Cervellini, Ilaria; Crippa, Donatella; Lauria, Giuseppe; Cavaletti, Guido; Cosimo Melcangi, Roberto

doi:10.1111/j.1529-8027.2009.00204.x

Public

Docetaxel‐induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model

Published in Journal of the Peripheral Nervous System • Mar 1, 2009

Authors:

Ilaria Roglio

Roberto Bianchi

Francesca Camozzi

Abstract

Peripheral neurotoxicity is a frequent complication limiting docetaxel chemotherapy in patients with cancer. We developed an experimental model that closely mimics the course of neuropathy in patients, aiming to investigate both the mechanisms of neurotoxicity at biochemical, functional and morpholo...

Subject

Docetaxel

Peripheral neuropathy

Medicine

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