Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

Heikkinen, Taneli; Lehtimäki, Kimmo; Vartiainen, Nina; Puoliväli, Jukka; J. Hendricks, Susan; R. Glaser, Jacob; Bradaïa, Amyaouch; Wadel, Kristian; Touller, Chrystelle; Kontkanen, Outi; Yrjänheikki, Juha; Buisson, Bruno; Howland, David; Beaumont, Vahri; Muñoz-Sanjuán, Ignacio; C. Park, Larry

doi:10.1371/journal.pone.0050717

Public

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

Published in PLoS ONE • Dec 20, 2012

Authors:

Taneli Heikkinen

Kimmo Lehtimäki

Nina Vartiainen

Abstract

Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene (HTT) mutation that causes the disease, several mouse lines have been developed using different gene constructs of Htt. ...

Subject

Striatum

Neuroscience

Huntington's disease

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!