Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load

Moulière, Florent; El Messaoudi, Safia; Gongora, Céline; Guedj, Anne-Sophie; Robert, Bruno; Del Rio, Maguy; Molina, Franck; Lamy, Pierre‐Jean; Lopez‐Crapez, Evelyne; Mathonnet, Muriel; Ychou, Marc; Pezet, Denis; R. Thierry, Alain

doi:10.1593/tlo.12445

Public

Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load

Published in Translational Oncology • Jun 1, 2013

Authors:

Florent Moulière

Safia El Messaoudi

Céline Gongora

Abstract

We used a novel method based on allele-specific quantitative polymerase chain reaction (Intplex) for the analysis of circulating cell.free DNA (ccfDNA) to compare total ccfDNA and KRAS- or BRAF-mutated ccfDNA concentrations in blood samples from mice xenografted with the human SW620 colorectal cance...

Subject

KRAS

Colorectal cancer

Mutation

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