IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

Lefrançais, Emma; Roga, Stéphane; Gautier, Violette; Gonzalez de Peredo, Anne; Monsarrat, Bernard; Girard, Jean‐Philippe; Cayrol, Corinne

doi:10.1073/pnas.1115884109

Public

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

Published in Proceedings of the National Academy of Sciences • Jan 17, 2012

Authors:

Emma Lefrançais

Stéphane Roga

Violette Gautier

Abstract

Interleukin-33 (IL-33) (NF-HEV) is a chromatin-associated nuclear cytokine from the IL-1 family, which has been linked to important diseases, including asthma, rheumatoid arthritis, ulcerative colitis, and cardiovascular diseases. IL-33 signals through the ST2 receptor and drives cytokine production...

Subject

Cathepsin G

Neutrophil elastase

Proteases

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