ATP Hydrolysis Is Critically Required for Function of Ca<sub>V</sub>1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca<sup>2+</sup>Clearance

Weiler, Simon; Krinner, Stefanie; B. Wong, Aaron; Moser, Tobias; Pangršič, Tina

doi:10.1523/jneurosci.4990-13.2014

Public

ATP Hydrolysis Is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca2+Clearance

Published in Journal of Neuroscience • May 14, 2014

Authors:

Simon Weiler

Stefanie Krinner

Aaron B. Wong

Abstract

Sound encoding is mediated by Ca(2+) influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca(2+) current through CaV1.3 channels and Ca(2+) homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca(2+) im...

Subject

Chemistry

Biophysics

Function (biology)

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