The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Cota, Daniela; Marsicano, Giovanni; H. Tschöp, Matthias; Grübler, Yvonne; Flachskamm, Cornelia; Schubert, Mirjam; P. Auer, Dorothee; Yassouridis, Alexander; Thöne‐Reineke, Christa; Ortmann, Sylvia; Tomassoni, Federica; Cervino, Cristina; Nisoli, Enzo; C. E. Linthorst, Astrid; Pasquali, Renato; Lutz, Beat; K. Stalla, Günter; Pagotto, Uberto

doi:10.1172/jci17725

Public

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Published in Journal of Clinical Investigation • Aug 1, 2003

Authors:

Daniela Cota

Giovanni Marsicano

Matthias H. Tschöp

Abstract

The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1-/...

Subject

Endocannabinoid system

Orexigenic

Cannabinoid receptor

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