Matrix metalloproteinase‐2 (MMP‐2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP‐ribose) polymerase (PARP) in vitro

Kwan, Jennifer; Schulze, Costas; Wang, Wenjie; León, Hernando; Sarıahmetoğlu, Meltem; M. Sung, Miranda; Sawicka, Jolanta; Sims, David; Sawicki, Grzegorz; Schulz, Richard

doi:10.1096/fj.02-1202fje

Public

Matrix metalloproteinase‐2 (MMP‐2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP‐ribose) polymerase (PARP) in vitro

Published in The FASEB Journal • Feb 6, 2004

Authors:

Jennifer Kwan

Costas Schulze

Wenjie Wang

Abstract

Matrix metalloproteinases (MMPs) are traditionally known for their role in extracellular matrix remodeling. Increasing evidence reveals several alternative substrates and novel biological roles for these proteases. Recent evidence showed the intracellular localization of MMP-2 within cardiac myocyte...

Subject

Poly ADP ribose polymerase

Matrix metalloproteinase

Nuclear matrix

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