NAD<sup>+</sup>Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

C. Alano, Conrad; Garnier, Philippe; Ying, Weihai; Higashi, Youichirou; M. Kauppinen, Tiina; A. Swanson, Raymond

doi:10.1523/jneurosci.5552-09.2010

Public

NAD+Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Published in Journal of Neuroscience • Feb 24, 2010

Authors:

Conrad C. Alano

Philippe Garnier

Weihai Ying

Abstract

Poly(ADP-ribose)-1 (PARP-1) is a key mediator of cell death in excitotoxicity, ischemia, and oxidative stress. PARP-1 activation leads to cytosolic NAD(+) depletion and mitochondrial release of apoptosis-inducing factor (AIF), but the causal relationships between these two events have been difficult...

Subject

NAD+ kinase

Poly ADP ribose polymerase

Apoptosis-inducing factor

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