A randomized phase I study of the safety and immunogenicity of three ascending dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults.

M, Nissen; H, Marshall; P, Richmond; S, Shakib; Q, Jiang; D, Cooper; D, Rill; J, Baber; J, Eiden; W, Gruber; KU, Jansen; EA, Emini; AS, Anderson; ET, Zito; D, Girgenti

doi:10.1016/j.vaccine.2015.02.024

Public

A randomized phase I study of the safety and immunogenicity of three ascending dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults.

Shared by NobleBlocks on Feb 21, 2015 • 12:00 AM UTC

Authors:

Nissen M

Marshall H

Richmond P

Abstract

Background Staphylococcus aureus is a common cause of healthcare-acquired morbidity and mortality and increased healthcare resource utilization. A prophylactic vaccine is being developed that may reduce this disease burden.Methods Volunteers in good general health aged 50-85 (n=312) and 18-24 (n=96)...

Subject

Staphylococcus aureus

Vaccine

Functional Antibodies

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