Ins(1,4,5) P 3 receptor-mediated Ca 2+ signaling and autophagy induction are interrelated

Decuypere, Jean-Paul; Welkenhuyzen, Kirsten; Luyten, Tomas; Ponsaerts, Raf; Dewaele, Michael; Molgó, Jordi; Agostinis, Patrizia; Missiaen, Ludwig; De Smedt, Humbert; B. Parys, Jan; Bultynck, Geert

doi:10.4161/auto.7.12.17909

Public

Ins(1,4,5) P 3 receptor-mediated Ca 2+ signaling and autophagy induction are interrelated

Published in Autophagy • Dec 1, 2011

Authors:

Jean-Paul Decuypere

Kirsten Welkenhuyzen

Tomas Luyten

Abstract

The role of intracellular Ca2+ signaling in starvation-induced autophagy remains unclear. Here, we examined Ca2+ dynamics during starvation-induced autophagy and the underlying molecular mechanisms. Tightly correlating with autophagy stimulation, we observed a remodeling of the Ca2+ signalosome. Fir...

Subject

Autophagy

Biology

Cell biology

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