Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

Wu, Xing; Liao, Liping; Liu, Xiangming; Luo, Fang; Yang, Tianming; Li, Chenhong

doi:10.4161/chan.22209

Public

Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

Published in Channels • Sep 18, 2012

Authors:

Xing Wu

Liping Liao

Xiangming Liu

Abstract

ZD7288 has been widely used as a tool in the study of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels), and to test the relationships between HCN channels and heart and brain function. ZD7288 is widely considered a selective blocker of HCN currents. Here we show that ZD728...

Subject

Hyperpolarization (physics)

HCN channel

Chemistry

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