Molecular mechanisms of HBV-associated hepatocarcinogenesis.
Published in Seminars in liver disease • May 1, 2013
Authors:,,
Francesca Guerrieri
Laura Belloni
Natalia Pediconi
Abstract
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV-DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer...
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