Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

C. Herold, Kevan; Hagopian, William; Auger, Julie; Poumian-Ruiz, Ena; Taylor, Lesley; Donaldson, David; E. Gitelman, Stephen; M. Harlan, David; Xu, Danlin; A. Zivin, Robert; A. Bluestone, Jeffrey

doi:10.1056/nejmoa012864

Public

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

Published in New England Journal of Medicine • May 30, 2002

Authors:

Kevan C. Herold

William Hagopian

Julie Auger

Abstract

BACKGROUND: Type 1 diabetes mellitus is a chronic autoimmune disease caused by the pathogenic action of T lymphocytes on insulin-producing beta cells. Previous clinical studies have shown that continuous immune suppression temporarily slows the loss of insulin production. Preclinical studies suggest...

Subject

Medicine

Monoclonal antibody

Diabetes mellitus

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