piggyBac is a flexible and highly active transposon as compared to Sleeping Beauty , Tol2 , and Mos1 in mammalian cells

Chiung‐Yuan Wu, Sareina; James Meir, Yaa‐Jyuhn; J. Coates, Craig; M. Handler, Alfred; Pelczar, Paweł; Moisyadi, Stefan; Kaminski, Joseph

doi:10.1073/pnas.0606979103

Public

piggyBac is a flexible and highly active transposon as compared to Sleeping Beauty , Tol2 , and Mos1 in mammalian cells

Published in Proceedings of the National Academy of Sciences • Sep 27, 2006

Authors:

Sareina Chiung‐Yuan Wu

Yaa‐Jyuhn James Meir

Craig J. Coates

Abstract

A nonviral vector for highly efficient site-specific integration would be desirable for many applications in transgenesis, including gene therapy. In this study we directly compared the genomic integration efficiencies of piggyBac, hyperactive Sleeping Beauty (SB11), Tol2, and Mos1 in four mammalian...

Subject

Transposase

Transposable element

Transposition (logic)

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