MHC-unrestricted lysis of MUC1-expressing cells by human peripheral blood mononuclear cells.

SE, Wright; KA, Rewers-Felkins; IS, Quinlin; WE, Fogler; CA, Phillips; M, Townsend; W, Robinson; R, Philip

doi:10.1080/08820130801967874

Public

MHC-unrestricted lysis of MUC1-expressing cells by human peripheral blood mononuclear cells.

Shared by NobleBlocks on Jan 1, 2008 • 12:00 AM UTC

Authors:

Wright SE

Rewers-Felkins KA

Quinlin IS

Abstract

Many human adenocarcinomas can be killed in vitro by targeted cytotoxic T-lymphocytes (CTL); however, major histocompatibility complex (MHC)-restrictions are typically required. The MUC1 antigen is common in many human adenocarcinomas, and is associated with a variable number of tandem repeats. It h...

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