Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions

Lee, Ji‐Won; Bae, Seong-Hui; Jeong, Joo‐Won; Kim, Se‐Hee; Kim, Kyu‐Won

doi:10.1038/emm.2004.1

Public

Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions

Published in Experimental & Molecular Medicine • Feb 1, 2004

Authors:

Ji‐Won Lee

Seong-Hui Bae

Joo‐Won Jeong

Abstract

Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha). The s...

Subject

Acetylation

Protein subunit

Hypoxia-Inducible Factor 1

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