Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

Abkevich, Victor; M. Timms, Kirsten; T. Hennessy, Bryan; Potter, Jennifer; Carey, Mark; Meyer, Lisa; Smith‐McCune, Karen; Broaddus, Russell; Lu, K.H.; Chen, J; Van Tran, Thuan; R. Williams, Deniece; Iliev, Diana; Jammulapati, Srikanth; M. FitzGerald, Liesel; C. Krivak, Thomas; A. DeLoia, Julie; Gutin, Alexander; B. Mills, Gordon; S. Lanchbury, J.

doi:10.1038/bjc.2012.451

Public

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

Published in British Journal of Cancer • Oct 9, 2012

Authors:

Victor Abkevich

Kirsten M. Timms

Bryan T. Hennessy

Abstract

BACKGROUND: Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance when used to support agents that introduce or exploit double-stranded DNA breaks. This study examines the association between homologous recombination defects and genom...

Subject

Loss of heterozygosity

Homologous recombination

Ovarian cancer

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