Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

A. Andersson, David; Gentry, Clive; Moss, Sian; Bevan, Stuart

doi:10.1523/jneurosci.5369-07.2008

Public

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

Published in Journal of Neuroscience • Mar 5, 2008

Authors:

David A. Andersson

Clive Gentry

Sian Moss

Abstract

Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory neurons where it acts as a sensor for environmental irritants, including acrolein, and some pungent plant ingredients such as allyl isothiocyanate and cinnamaldehyde. These exogenous compounds activate TRPA1 by c...

Subject

Transient receptor potential channel

Chemistry

Dorsal root ganglion

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