Treatment and prognostic impact of transient leukemia in neonates with Down syndrome.

JH, Klusmann; U, Creutzig; M, Zimmermann; M, Dworzak; N, Jorch; C, Langebrake; A, Pekrun; K, Macakova-Reinhardt; D, Reinhardt

doi:10.1182/blood-2007-10-118810

Public

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome.

Shared by NobleBlocks on Jan 8, 2008 • 12:00 AM UTC

Authors:

Klusmann JH

Creutzig U

Zimmermann M

Abstract

Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient leukemia (TL). Though TL resolves spontaneously in most patients, early death and development of myeloid leukemia (ML-DS) may occur. Prognostic factors as well as treatment indication are currently uncertain. To res...

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