The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling

Seillet, Cyril; Laffont, Sophie; Trémollières, Florence; Rouquié, Nelly; Ribot, C; Arnal, Jean‐François; Douin‐Echinard, Victorine; Gourdy, Pierre; Guéry, Jean‐Charles

doi:10.1182/blood-2011-08-371831

Public

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling

Published in Blood • Nov 18, 2011

Authors:

Cyril Seillet

Sophie Laffont

Florence Trémollières

Abstract

Plasmacytoid dendritic cells (pDCs) produce large amounts of type I interferons (IFN-α/β) in response to viral or endogenous nucleic acids through activation of their endosomal Toll-like receptors (TLR-7 and TLR-9). Enhanced TLR-7-mediated IFN-α production by pDCs in women, compared with men, has be...

Subject

Cell biology

In vivo

Plasmacytoid dendritic cell

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