PPARγ Controls Dectin-1 Expression Required for Host Antifungal Defense against Candida albicans

Galès, Amandine; Conduché, Annabelle; Bernad, José; Lefèvre, Lise; Olagnier, David; Béraud, Maryse; Martin‐Blondel, Guillaume; Linas, Marie-Denise; Auwerx, Johan; Coste, Agnès; Pipy, Bernard

doi:10.1371/journal.ppat.1000714

Public

PPARγ Controls Dectin-1 Expression Required for Host Antifungal Defense against Candida albicans

Published in PLoS Pathogens • Jan 8, 2010

Authors:

Amandine Galès

Annabelle Conduché

José Bernad

Abstract

We recently showed that IL-13 or peroxisome proliferator activated receptor gamma (PPARgamma) ligands attenuate Candida albicans colonization of the gastrointestinal tract. Here, using a macrophage-specific Dectin-1 deficient mice model, we demonstrate that Dectin-1 is essential to control fungal ga...

Subject

Candida albicans

Antifungal

Microbiology

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