PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans.

A, Galès; A, Conduché; J, Bernad; L, Lefevre; D, Olagnier; M, Béraud; G, Martin-Blondel; MD, Linas; J, Auwerx; A, Coste; B, Pipy

doi:10.1371/journal.ppat.1000714

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PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans.

Shared by NobleBlocks on Jan 8, 2010 • 12:00 AM UTC

Authors:

Galès A

Conduché A

Bernad J

Abstract

We recently showed that IL-13 or peroxisome proliferator activated receptor gamma (PPARgamma) ligands attenuate Candida albicans colonization of the gastrointestinal tract. Here, using a macrophage-specific Dectin-1 deficient mice model, we demonstrate that Dectin-1 is essential to control fungal ga...

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