Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1

Qian, Chengmin; Li, SiDe; Jakoncic, Jean; Zeng, Lei; J. Walsh, Martin; Zhou, Ming‐Ming

doi:10.1074/jbc.c800169200

Public

Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1

Published in Journal of Biological Chemistry • Oct 23, 2008

Authors:

Chengmin Qian

SiDe Li

Jean Jakoncic

Abstract

Human UHRF1 (ubiquitin-like PHD and RING finger 1) functions to maintain CpG DNA methylation patterns through DNA replication by co-localizing with the DNA methyltransferase DNMT1 at chromatin in mammals. Recent studies show that UHRF1 binds selectively to hemimethylated CpG via its conserved SRA (S...

Subject

DNA methylation

DNA methyltransferase

Biology

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