Predictive DNA Testing and Prophylactic Thyroidectomy in Patients at Risk for Multiple Endocrine Neoplasia Type 2A

A. Wells, Samuel; David, Doina; Toshima, Koji; P. Dehner, Louis; M. Coffin, Cheryl; Bruce Dowton, S.; Ivanovich, Jennifer; K. DeBenedettl, Mary; G. Dilley, William; F. Moley, Jeffrey; A. Norton, Jeffrey; Donis-Keller, Helen

doi:10.1097/00000658-199409000-00002

Public

Predictive DNA Testing and Prophylactic Thyroidectomy in Patients at Risk for Multiple Endocrine Neoplasia Type 2A

Published in Annals of Surgery • Sep 1, 1994

Authors:

Samuel A. Wells

Doina David

Koji Toshima

Abstract

BACKGROUND: Missense germ-line mutations in the RET protooncogene are associated with multiple endocrine neoplasia type 2A (MEN 2A). Detection of these mutant alleles in kindred members predicts disease inheritance and provides the basis for preventative thyroidectomy. METHODS: A polymerase chain re...

Subject

Medicine

Thyroid carcinoma

Missense mutation

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