Pharmacokinetics and Pharmacodynamics of Zoledronic Acid in Cancer Patients with Bone Metastases

Chen, Tianling; Berenson, James; Vescio, Robert; Swift, Regina; Gilchick, Alicia; Goodin, Susan; LoRusso, Patricia; Ma, Peiming; Ravera, Christina; Deckert, Fabienne; Schran, Horst; Seaman, John; Skerjanec, Andrej

doi:10.1177/009127002762491316

Public

Pharmacokinetics and Pharmacodynamics of Zoledronic Acid in Cancer Patients with Bone Metastases

Shared by NobleBlocks on Nov 1, 2002 • 12:00 AM UTC

Authors:

Tianling Chen

James Berenson

Robert Vescio

Abstract

The pharmacokinetics, pharmacodynamics, and safety of zoledronic acid (Zometa®), a new‐generation bisphosphonate, were evaluated in 36 patients with cancer and bone metastases. Zoledronic acid (by specific radioimmunoassay) and markers of bone turnover were determined in plasma and urine after three...

Discussions