Functional linkage of cirrhosis‐predictive single nucleotide polymorphisms of toll‐like receptor 4 to hepatic stellate cell responses†‡

J, Guo; Loke, Johnny; Zheng, Feng; Hong, Feng; Yea, Steven; Fukata, Masayuki; Tarocchi, Mirko; T. Abar, Olivia; Huang, Hongjin; J. Sninsky, John; L. Friedman, Scott

doi:10.1002/hep.22697

Public

Functional linkage of cirrhosis‐predictive single nucleotide polymorphisms of toll‐like receptor 4 to hepatic stellate cell responses†‡

Published in Hepatology • Nov 13, 2008

Authors:

Guo J

Johnny Loke

Feng Zheng

Abstract

UNLABELLED: In a recent study, a single nucleotide polymorphism (SNP) of the Toll-like receptor 4 (TLR4) gene (c.1196C>T [rs4986791, p.T399I]) emerged as conferring protection from fibrosis progression compared to a major, wild-type (WT) CC allele (p.T399). The present study examined the functional ...

Subject

Cirrhosis

Hepatic stellate cell

Single-nucleotide polymorphism

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