DNA hypomethylation and proliferative activity are increased in the rectal mucosa of patients with long-standing ulcerative colitis.

Glória, L; Cravo, M; Pinto, A; S de Sousa, L; Chaves, P; N Leitão, C; Quina, M; C Mira, F; Soares, J

doi:10.1002/(sici)1097-0142(19961201)78:11<2300::aid-cncr5>3.0.co;2-q

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DNA hypomethylation and proliferative activity are increased in the rectal mucosa of patients with long-standing ulcerative colitis.

Shared by NobleBlocks on Dec 1, 1996 • 12:00 AM UTC

Authors:

L Glória

M Cravo

A Pinto

Abstract

BACKGROUND: DNA methylation and DNA cytometric parameters were evaluated in the rectal mucosa from patients with extensive and long-standing ulcerative colitis. METHODS: Twenty-six patients with extensive disease for more than 7 years and 11 healthy controls were included. Global DNA methylation was...

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