Immunologic tolerance maintained by CD25<sup>+</sup> CD4<sup>+</sup> regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Sakaguchi, Shimon; Sakaguchi, Noriko; Shimizu, Jun; Yamazaki, Sayuri; Sakihama, Toshiko; Itoh, Misako; Kuniyasu, Yuhshi; Nomura, Takashi; Toda, Masaaki; Takahashi, Takeshi

doi:10.1034/j.1600-065x.2001.1820102.x

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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Shared by NobleBlocks on Aug 1, 2001 • 12:00 AM UTC

Authors:

Shimon Sakaguchi

Noriko Sakaguchi

Jun Shimizu

Abstract

Summary: There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T‐cell population have revealed that CD25 + cell...

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