Mutations in <i>GNA11</i> in Uveal Melanoma

D. Van Raamsdonk, Catherine; Griewank, Klaus; B. Crosby, Michelle; C. Garrido, María; S. Vemula, Swapna; Wiesner, Thomas; C. Obenauf, Anna; Wackernagel, Werner; Green, Gary; Bouvier, Nancy; Sozen, Mert; Baimukanova, Gail; Roy, Ritu; Heguy, Adriana; Dolgalev, Igor; Khanin, Raya; J. Busam, Klaus; R. Speicher, Michael; M. O’Brien, Joan; C. Bastian, Boris

doi:10.1056/nejmoa1000584

Public

Mutations in GNA11 in Uveal Melanoma

Published in New England Journal of Medicine • Nov 17, 2010

Authors:

Catherine D. Van Raamsdonk

Klaus Griewank

Michelle B. Crosby

Abstract

BACKGROUND: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. METHODS: We sequenced exon 5 of GNAQ and GNA11, a paralo...

Subject

GNAQ

Melanoma

Cancer research

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