Co‐administration of proton pump inhibitors delays elimination of plasma methotrexate in high‐dose methotrexate therapy

Suzuki, Kunihiro; Doki, Kosuke; Homma, Masato; Tamaki, Hirofumi; Hori, Satoko; Ohtani, Hisakazu; Sawada, Yasufumi; Kohda, Yukinao

doi:10.1111/j.1365-2125.2008.03303.x

Public

Co‐administration of proton pump inhibitors delays elimination of plasma methotrexate in high‐dose methotrexate therapy

Shared by NobleBlocks on Dec 22, 2008 • 12:00 AM UTC

Authors:

Kunihiro Suzuki

Kosuke Doki

Masato Homma

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Co‐administration of proton pump inhibitors (PPIs) increases plasma methotrexate (MTX) concentration in cancer patients receiving high‐dose MTX (HDMTX) therapy. • There is controversy as to whether or not co‐administration of PPIs affects plasma MTX elimina...

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