ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells

Hu, Pengfei; Lai, Dongwu; Lu, Peilin; Gao, Jing; He, Hong

doi:10.3892/ijmm.2012.891

Public

ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells

Published in International Journal of Molecular Medicine • Jan 23, 2012

Authors:

Pengfei Hu

Dongwu Lai

Peilin Lu

Abstract

Advanced glycation end products (AGEs) play an important role in the proliferation of vascular smooth muscle cells (VSMCs) and accelerate atherosclerosis in diabetic patients. Autophagy, a life-sustaining process, is stimulated in atherosclerotic plaques by oxidized lipids, inflammation and metaboli...

Subject

Autophagy

Glycation

Vascular smooth muscle

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