DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1

N. De Iuliis, Geoffry; Kelly Thomson, Laura; A. Mitchell, Lisa; M. Finnie, Jane; J. Koppers, Adam; Hedges, Andrew; Nixon, Brett; John Aitken, R.

doi:10.1095/biolreprod.109.076836

Public

DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1

Published in Biology of Reproduction • Jun 4, 2009

Authors:

Geoffry N. De Iuliis

Laura Kelly Thomson

Lisa A. Mitchell

Abstract

DNA damage in human spermatozoa has been associated with a range of adverse clinical outcomes, including infertility, abortion, and disease in the offspring. We have advanced a two-step hypothesis to explain this damage involving impaired chromatin remodeling during spermiogenesis followed by a free...

Subject

Biology

Chromatin

DNA damage

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