H+-induced Membrane Insertion of Influenza Virus Hemagglutinin Involves the HA2 Amino-terminal Fusion Peptide but Not the Coiled Coil Region

Durrer, Peter; Galli, Carmela; Hoenke, Stefan; Corti, Chantal; Glück, Reinhard; Vorherr, Thomas; Brunner, Josef

doi:10.1074/jbc.271.23.13417

Public

H+-induced Membrane Insertion of Influenza Virus Hemagglutinin Involves the HA2 Amino-terminal Fusion Peptide but Not the Coiled Coil Region

Published in Journal of Biological Chemistry • Jun 1, 1996

Authors:

Peter Durrer

Carmela Galli

Stefan Hoenke

Abstract

Fusion of influenza virus with target membranes is induced by acid and involves complex changes in the viral envelope protein hemagglutinin (HA). In a first, kinetically distinct step, the HA polypeptide chain 2 (HA2) is inserted into the target membrane bilayer. Using hydrophobic photolabeling with...

Subject

Lipid bilayer fusion

Hemagglutinin (influenza)

Membrane

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