H+-induced membrane insertion of influenza virus hemagglutinin involves the HA2 amino-terminal fusion peptide but not the coiled coil region.

P, Durrer; C, Galli; S, Hoenke; C, Corti; R, Glück; T, Vorherr; J, Brunner

doi:10.1074/jbc.271.23.13417

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H+-induced membrane insertion of influenza virus hemagglutinin involves the HA2 amino-terminal fusion peptide but not the coiled coil region.

Shared by NobleBlocks on Jun 1, 1996 • 12:00 AM UTC

Authors:

Durrer P

Galli C

Hoenke S

Abstract

Fusion of influenza virus with target membranes is induced by acid and involves complex changes in the viral envelope protein hemagglutinin (HA). In a first, kinetically distinct step, the HA polypeptide chain 2 (HA2) is inserted into the target membrane bilayer. Using hydrophobic photolabeling with...

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