Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

Lawitz, Eric; Mangia, Alessandra; Wyles, David; Rodríguez‐Torres, M.; Hassanein, Tarek; C. Gordon, Stuart; Schultz, Michael; Davis, Mitchell; Kayali, Zeid; Rajender Reddy, K.; M. Jacobson, Ira; V. Kowdley, Kris; M. Nyberg, Lisa; Mani Subramanian, G.; H. Hyland, Robert; Arterburn, Sarah; Jiang, Deyuan; McNally, John; M. Brainard, Diana; T. Symonds, William; G. McHutchison, John; Sheikh, Aasim; M. Younossi, Zobair; Gane, Edward

doi:10.1056/nejmoa1214853

Public

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

Published in New England Journal of Medicine • Apr 23, 2013

Authors:

Eric Lawitz

Alessandra Mangia

David Wyles

Abstract

BACKGROUND: In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with chronic hepatitis C virus (HCV) genotype 1, 2, or 3 infection. METHODS: We conducted two phase 3 studies in previously untreated patients with HCV infection. In a single-...

Subject

Medicine

Sofosbuvir

Chronic hepatitis

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