A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, Weiqi; Li, Jingyi; Suzuki, Keiichiro; Qu, Jing; Wang, Ping; Zhou, Junzhi; Liu, Xiaomeng; Ren, Ruotong; Xu, Xiuling; Ocampo, Alejandro; Yuan, Tingting; Yang, Jiping; Li, Ying; Shi, Liang; Guan, Dee; Pan, Huize; Duan, Shunlei; Ding, Zhichao; Li, Mo; Yi, Fei; Bai, Ruijun; Wang, Yayu; Chen, Chang; Yang, Fuquan; Li, Xiaoyu; Wang, Zimei; Aizawa, Emi; Goebl, April; Devi Soligalla, Rupa; Reddy, Pradeep; Rodrı́guez Esteban, Concepción; Tang, Fuchou; Liu, Guang‐Hui; Carlos Izpisúa Belmonte, Juan

doi:10.1126/science.aaa1356

Public

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Published in Science • Apr 30, 2015

Authors:

Weiqi Zhang

Jingyi Li

Keiichiro Suzuki

Abstract

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a glo...

Subject

Heterochromatin

Premature aging

Werner syndrome

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!