Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures

A. Cavalheiro, Ésper; Pereira Leite, João; A Bortolotto, Z; A. Turski, Waldemar; Ikonomidou, Chrysanthy; Turski, L.

doi:10.1111/j.1528-1157.1991.tb05533.x

Public

Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures

Published in Epilepsia • Dec 1, 1991

Authors:

Ésper A. Cavalheiro

João Pereira Leite

Z A Bortolotto

Abstract

Summary: Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic diseases, toxins, drug‐induced seizures) may lead to chronic epilepsy in survivors. Epidemiologic analyses show that a considerable ...

Subject

Kindling

Pilocarpine

Epilepsy

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