Effect of IGF-I in the Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in the Presence or Absence of TGF-β Signaling

Longobardi, Lara; O'Rear, Lynda; Aakula, Srikanth; Johnstone, Brian; Shimer, Kimberly; Chytil, Anna; A Horton, William; L Moses, Harold; Spagnoli, Anna

doi:10.1359/jbmr.051213

Public

Effect of IGF-I in the Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in the Presence or Absence of TGF-β Signaling

Shared by NobleBlocks on Apr 1, 2006 • 12:00 AM UTC

Authors:

Lara Longobardi

Lynda O'Rear

Srikanth Aakula

Abstract

Abstract A novel role for IGF-I in MSC chondrogenesis was determined. IGF-I effects were evaluated in the presence or absence of TGF-β signaling by conditionally inactivating the TGF-β type II receptor. We found that IGF-I had potent chondroinductive actions on MSCs. IGF-I effects were independent f...

Discussions