Effect of IGF-I in the Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in the Presence or Absence of TGF-β Signaling

Longobardi, Lara; O’Rear, Lynda; Aakula, Srikanth; H. Johnstone, Brian; Shimer, Kimberly; Chytil, Anna; A. Horton, William; L. Moses, Harold; Spagnoli, Anna

doi:10.1359/jbmr.051213

Public

Effect of IGF-I in the Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in the Presence or Absence of TGF-β Signaling

Published in Journal of Bone and Mineral Research • Apr 1, 2006

Authors:

Lara Longobardi

Lynda O’Rear

Srikanth Aakula

Abstract

UNLABELLED: A novel role for IGF-I in MSC chondrogenesis was determined. IGF-I effects were evaluated in the presence or absence of TGF-beta signaling by conditionally inactivating the TGF-beta type II receptor. We found that IGF-I had potent chondroinductive actions on MSCs. IGF-I effects were inde...

Subject

Chondrogenesis

Mesenchymal stem cell

Cell biology

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