A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

Okada, Chimari; Yamashita, Eiki; Jae Lee, Soo; Shibata, Satoshi; Katahira, Jun; Nakagawa, Atsushi; Yoneda, Yoshihiro; Tsukihara, Tomitake

doi:10.1126/science.1178705

Public

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

Published in Science • Nov 27, 2009

Authors:

Chimari Okada

Eiki Yamashita

Soo Jae Lee

Abstract

Nuclear export of microRNAs (miRNAs) by exportin-5 (Exp-5) is an essential step in miRNA biogenesis. Here, we present the 2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed with Exp-5 and a guanine triphosphate (GTP)-bound form of the small nuclear guanine...

Subject

Ran

Nuclear export signal

Nuclear transport

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!