Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Luz‐Crawford, Patricia; Kurte, Mónica; Bravo‐Alegria, Javiera; Contreras, Rafaël; Nova‐Lamperti, Estefanía; Téjédor, Gautier; Noël, Danièle; Jørgensen, Christian; Figueroa, Fernando; Djouad, Farida; Carrión, Flavio

doi:10.1186/scrt216

Public

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Published in Stem Cell Research & Therapy • Jun 4, 2013

Authors:

Patricia Luz‐Crawford

Mónica Kurte

Javiera Bravo‐Alegria

Abstract

INTRODUCTION: Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes, which appear responsible for causing autoimmune disease, have yet to be full...

Subject

Mesenchymal stem cell

IL-2 receptor

FOXP3

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