Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans

James B. Dyck, P.; J Peroutka, S; A. Rask, C.; C. Burton, Elizabeth; K. Baker, Michael; A. Lehman, Kenneth; Gillen, Derek; L. Hokanson, J.; C. O’Brien, Peter

doi:10.1212/wnl.48.2.501

Public

Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans

Published in Neurology • Feb 1, 1997

Authors:

P. James B. Dyck

S J Peroutka

C. A. Rask

Abstract

Nerve growth factor (NGF) plays a biologic role in the development and maintenance of sympathetic and small sensory neurons. Because it facilitates nerve fiber regeneration, lowers heat-pain threshold (hyperalgesia), and prevents or improves nerve dysfunction in experimental neuropathy, it is being ...

Subject

Allodynia

Medicine

Hyperalgesia

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