5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

Vincent, Julie; Mignot, Grégoire; Chalmin, Fanny; Ladoire, Sylvain; Bruchard, Mélanie; Chevriaux, Angélique; Martin, François; Apétoh, Lionel; Rébé, Cédric; Ghiringhelli, François

doi:10.1158/0008-5472.can-09-3690

Public

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

Published in Cancer Research • Apr 13, 2010

Authors:

Julie Vincent

Grégoire Mignot

Fanny Chalmin

Abstract

Myeloid-derived suppressor cells (MDSC) accumulate in the spleen and tumor bed during tumor growth. They contribute to the immune tolerance of cancer notably by inhibiting the function of CD8(+) T cells. Thus, their elimination may hamper tumor growth by enhancing antitumor T-cell functions. We have...

Subject

Cytotoxic T cell

In vivo

Cancer research

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