Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

Eun Park, Jung; Sen Tan, Hon; Datta, Arnab; Chai Lai, Ruenn; Zhang, Huoming; Meng, Wei; Kiang Lim, Sai; Kwan Sze, Siu

doi:10.1074/mcp.m900381-mcp200

Public

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

Published in Molecular & Cellular Proteomics • Feb 1, 2010

Authors:

Jung Eun Park

Hon Sen Tan

Arnab Datta

Abstract

Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or reoxygenated A431 carcinoma cells exhibited enhanced angiogenic and metastatic potential such as reduced cell-cell and cell-extracel...

Subject

Microvesicles

Angiogenesis

Cell biology

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