ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

Lazarowski, Alberto; Czornyj, Liliana; Lubienieki, Fabiana; Girardi, Elena; Vázquez, Silvia; D’Giano, Carlos

doi:10.1111/j.1528-1167.2007.01302.x

Public

ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

Published in Epilepsia • Sep 1, 2007

Authors:

Alberto Lazarowski

Liliana Czornyj

Fabiana Lubienieki

Abstract

It is estimated 20-25% of the epileptic patients fails to achieve good control with the different antiepileptic drugs (AEDs) treatments, developing refractory epilepsy (RE). Discovered first in cancer, the activity of P-glycoprotein (P-gp) and others ABC transporters as multidrug-resistance-associat...

Subject

Epilepsy

Abcg2

P-glycoprotein

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