Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide.

CF, Deacon; MA, Nauck; J, Meier; K, Hücking; JJ, Holst

doi:10.1210/jcem.85.10.6855

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Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide.

Shared by NobleBlocks on Oct 1, 2000 • 12:00 AM UTC

Authors:

Deacon CF

Nauck MA

Meier J

Abstract

Gastric inhibitory polypeptide (GIP) is susceptible to degradation, but only recently has dipeptidyl peptidase IV been identified as the enzyme responsible. Most RIAs recognize both intact GIP-(1-42) and the noninsulinotropic N-terminally truncated metabolite, GIP-(3-42), hampering measurement of pl...

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