Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide<sup>1</sup>

F. Deacon, Carolyn; A. Nauck, Michael; J. Meier, Juris; Hücking, Katrin; J. Holst, Jens

doi:10.1210/jcem.85.10.6855

Public

Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide1

Published in The Journal of Clinical Endocrinology & Metabolism • Oct 1, 2000

Authors:

Carolyn F. Deacon

Michael A. Nauck

Juris J. Meier

Abstract

Gastric inhibitory polypeptide (GIP) is susceptible to degradation, but only recently has dipeptidyl peptidase IV been identified as the enzyme responsible. Most RIAs recognize both intact GIP-(1-42) and the noninsulinotropic N-terminally truncated metabolite, GIP-(3-42), hampering measurement of pl...

Subject

Gastric inhibitory polypeptide

Endocrinology

Metabolite

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