A Novel Role for Thyroid-Stimulating Hormone: Up-Regulation of Hepatic 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A Reductase Expression Through the Cyclic Adenosine Monophosphate/Protein Kinase A/Cyclic Adenosine Monophosphate–Responsive Element Binding Protein Pathway

Tian, Limin; Song, Yongfeng; Xing, Mingzhao; Zhang, Wei; Ning, Guang; Li, Xiaoying; Yu, Chunxiao; Qin, Chengkong; Liu, Jun; Tian, Xingsong; Sun, Xianglan; Fu, Rui; Zhang, Lin; Zhang, Xiujuan; Lu, Yan; Zou, Jianwen; Wang, Laicheng; Guan, Qingbo; Gao, Ling; Zhao, Jiajun

doi:10.1002/hep.23800

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A Novel Role for Thyroid-Stimulating Hormone: Up-Regulation of Hepatic 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A Reductase Expression Through the Cyclic Adenosine Monophosphate/Protein Kinase A/Cyclic Adenosine Monophosphate–Responsive Element Binding Protein Pathway

Shared by NobleBlocks on Oct 1, 2010 • 12:00 AM UTC

Authors:

Limin Tian

Yongfeng Song

Mingzhao Xing

Abstract

Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that in liver cells, TSH promoted the expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reduct...

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