Rapid endo‐lysosomal escape of poly(DL‐lactide‐
                    <i>co</i>
                    glycolide) nanoparticles: implications for drug and gene delivery

Panyam, Jayanth; Zhou, Wen‐Zhong; Prabha, Swayam; K. Sahoo, Sanjeeb; Labhasetwar, Vinod

doi:10.1096/fj.02-0088com

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Rapid endo‐lysosomal escape of poly(DL‐lactide‐ co glycolide) nanoparticles: implications for drug and gene delivery

Shared by NobleBlocks on Aug 1, 2002 • 12:00 AM UTC

Authors:

Jayanth Panyam

Wen‐Zhong Zhou

Swayam Prabha

Abstract

ABSTRACT The endo‐lysosomal escape of drug carriers is crucial to enhancing the efficacy of their macromolecular payload, especially the payloads that are susceptible to lysosomal degradation. Current vectors that enable the endo‐lysosomal escape of macromolecules such as DNA are limited by their to...

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